A glimpse into my portfolio of bioinformatics projects.
As part of a student team during the first year of my PhD, I worked with the Boston Undiagnosed Diseases Network chapter to pinpoint the underlying genetic causes of two rare diseases in young patients. We built a machine learning classifier to go from variant to diagnosis and found the likely cause for one of the two children.
Identified novel cancer vulnerabilities using a protein network-based approach to find networks under purifying selection in tumors.
Pinpointed epistatic interactions to enable a phenotype-genotype bridge in autism using coalitional game theory.
Characterized the mutational landscape of lung cancers with respect to therapeutic and clinical actionability.
Assessed potential synergy between various anti-melanoma drugs from gene expression signatures in response to these therapies.
Engineered bacteria to sense inflammation in the gut and secrete anti-inflammatory agents in response.